PPFIA1

Across TCGA patient cohorts, PPFIA1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIA1-associated genes across cancer lineages are ASNS, Cyclin-B1, and Cyclin-E1. Each is linked with PPFIA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIA1-to-partner and partner-to-PPFIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PPFIA1-low versus PPFIA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA1→partner) and Y-score (partner→PPFIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.402	+1.807	<.001	.003	3	3
UCEC	Cyclin-B1 →	+0.781	+2.222	<.001	<.001	3	3
UCEC	Cyclin-E1 →	+0.291	+2.115	.029	.016	3	3
SKCM	14-3-3_beta →	-0.126	-2.459	.042	.020	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.489	.019	.025	3	2
UCEC	PDCD4 →	-0.573	-2.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by PPFIA1 expression — UCEC

Explore this box plot interactively →