PPDPFL

Across TCGA pan-cancer cohorts, PPDPFL RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PPDPFL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPDPFL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPDPFL is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where PPDPFL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPDPFL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+2.252	<.001	12	view →
HNSC	Male	All	−1.774	<.001	8	view →
BRCA	All	All	−0.220	.007	4	view →
KICH	All	All	−0.013	.011	3	view →
COAD	All	IV	−0.034	.044	2	view →
BLCA	All	IV	−0.524	.038	1	view →
LUSC	All	All	+0.208	.044	1	view →
LIHC	Female	All	−0.019	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PPDPFL–KIRC

Open the KIRC breakdown →