PPCS

Across TCGA pan-cancer cohorts, PPCS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPCS data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPCS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPCS expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where PPCS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.435	0.783	<.001	72	view →
HNSC	DFS	Median	All	0.895	0.670	.001	39	view →
UCEC	OS	Tertile	III,IV	1.000	0.319	.017	26	view →
PDAC	DFS	Quartile	III,IV	0.643	0.282	.003	14	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	13	view →
GBM	OS	Quartile	All	0.691	0.922	.003	10	view →
LSCC	DFS	Median	II,III,IV	0.988	0.841	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPCS–LUAD (DFS)

Open the LUAD breakdown →