PPCS

Across TCGA patient cohorts, PPCS protein abundance is significantly associated with the RNA expression of many other genes, with 14,101 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPCS-associated genes across cancer lineages are ATP6V0B, MYCBP, and C1orf210. Each is linked with PPCS in more than 5 cancer types. Because this analysis shows association rather than direction, both PPCS-to-partner and partner-to-PPCS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPCS versus ATP6V0B in UCEC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPCS→partner) and Y-score (partner→PPCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V0B →	+0.723	+0.198	.003	.005	3	6
UCEC	MYCBP →	+0.576	+0.426	<.001	<.001	3	6
HNSC	C1orf210 →	+0.821	+0.228	<.001	<.001	3	6
UCEC	IPO13 →	+0.699	+0.274	.003	<.001	3	5
OV	ERI3 →	+0.492	+0.484	.001	.008	3	5
OV	MEAF6 →	+0.537	+0.528	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,101 associations by consensus.

PPCS vs ATP6V0B — UCEC

Explore this scatter interactively →