PPCS

Across TCGA patient cohorts, PPCS mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPCS-associated genes across cancer lineages are Rictor_pT1135, A-Raf_pS299, and ERK2. Each is linked with PPCS in more than 1 cancer types. Because this analysis shows association rather than direction, both PPCS-to-partner and partner-to-PPCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by PPCS-low versus PPCS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPCS→partner) and Y-score (partner→PPCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.097	-2.000	.035	.032	3	2
UCEC	A-Raf_pS299 →	-0.159	-2.000	.003	.032	3	1
UCEC	ERK2 →	+0.223	+3.169	.010	.019	3	1
UCEC	ACC_pS79 →	+0.439	+3.009	.004	.019	3	1
UCEC	JNK2 →	+0.293	+2.700	.001	.006	3	1
UCEC	PCNA →	+0.225	+3.169	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Rictor_pT1135 by PPCS expression — UCEC

Explore this box plot interactively →