PPCDC

Across TCGA pan-cancer cohorts, PPCDC RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPCDC’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PPCDC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPCDC is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

BLCA, LIHC, and STAD are the cancer types where PPCDC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPCDC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.715	<.001	11	view →
LIHC	Female	II,III,IV	+1.170	<.001	9	view →
STAD	Male	II,III,IV	+0.559	<.001	8	view →
BRCA	All	All	+0.338	<.001	6	view →
KIRC	All	All	+0.203	.001	6	view →
CHOL	Female	All	+2.170	<.001	5	view →
UCEC	All	III,IV	+0.599	.014	4	view →
KICH	All	All	−0.413	.001	3	view →
PRAD	All	All	+0.181	.016	2	view →
ESCA	All	All	+0.511	.020	1	view →
KIRP	All	All	−0.258	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPCDC–BLCA

Open the BLCA breakdown →