PPCDC

Across TCGA pan-cancer cohorts, PPCDC mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPCDC’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PPCDC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPCDC is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where PPCDC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPCDC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.587	<.001	9	view →
HNSC	Male	III,IV	−0.409	<.001	8	view →
PDAC	Male	II,III,IV	−0.555	<.001	7	view →
LSCC	Male	All	−0.355	<.001	7	view →
OV	All	All	−0.331	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPCDC–LUAD

Open the LUAD breakdown →