Across TCGA patient cohorts, PPARA mutation is significantly associated with the RNA expression of many other genes, with 2,560 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPARA-associated genes across cancer lineages are RN7SL82P, ST13P16, and MRPL51P2. Each is linked with PPARA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARA-to-partner and partner-to-PPARA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARA→partner) and Y-score (partner→PPARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL82P →	+0.128	+7.731	<.001	.009	3	2
CESC	ST13P16 →	+0.094	+3.760	.001	.007	3	2
LIHC	MRPL51P2 →	+0.082	+5.584	<.001	.001	3	2
CESC	RNU6-416P →	+0.218	+4.984	<.001	.003	3	2
CESC	PWRN4 →	+0.139	+4.984	<.001	.003	3	2
BRCA	MIR4318 →	+0.324	+8.055	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,560 associations by consensus.

Exploration

PPARA survival (RNA) · tumor vs normal (RNA) · all PPARA data types