Across TCGA patient cohorts, PPARA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPARA-associated genes across cancer lineages are 4E-BP1, JNK2, and ER-alpha. Each is linked with PPARA in more than 2 cancer types. Because this analysis shows association rather than direction, both PPARA-to-partner and partner-to-PPARA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARA→partner) and Y-score (partner→PPARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.228	+2.145	.011	.009	3	3
UCEC	JNK2 →	+0.220	+2.142	<.001	.009	3	2
UCEC	ER-alpha →	+0.585	+1.713	.033	.024	3	1
UCEC	A-Raf_pS299 →	-0.127	-2.700	.001	.005	3	1
UCEC	ERK2 →	+0.153	+2.201	.017	<.001	3	1
UCEC	INPP4B →	-0.237	-2.584	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PPARA survival (RNA) · tumor vs normal (RNA) · all PPARA data types