Across TCGA cell cohorts, PPARA mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPARA-associated genes across cancer lineages are AGTR2, OR5P2, and LCE2C. Each is linked with PPARA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARA-to-partner and partner-to-PPARA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARA→partner) and Y-score (partner→PPARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AGTR2 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR5P2 →	+0.028	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.031	+4.662	<.001	.005	3	1
LARGE_INTESTINE	VAX1 →	+0.624	+3.519	.001	.007	3	1
LARGE_INTESTINE	C10orf53 →	+0.015	+4.047	<.001	<.001	3	1
BLOOD_Leukemia	PTCHD1 →	+0.746	+4.133	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

PPARA survival (RNA) · tumor vs normal (RNA) · all PPARA data types