PPA2

Across TCGA patient cohorts, PPA2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPA2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ACC1. Each is linked with PPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPA2-to-partner and partner-to-PPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPA2-low versus PPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPA2→partner) and Y-score (partner→PPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-2.673	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.180	-2.906	<.001	.001	3	1
UCEC	ACC1 →	+0.291	+2.183	.037	.033	3	1
UCEC	HSP70 →	-0.336	-2.449	.029	.019	3	1
UCEC	INPP4B →	-0.340	-3.321	.006	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.249	-3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by PPA2 expression — UCEC

Explore this box plot interactively →