PPA1

Across TCGA pan-cancer cohorts, PPA1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PPA1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and COAD are the cancer types where PPA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.866	0.657	<.001	83	view →
LUAD	OS	Tertile	III,IV	1.000	0.467	.004	20	view →
COAD	DFS	Median	IV	0.493	0.944	.031	18	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	12	view →
LSCC	DFS	Quartile	All	0.912	0.188	.002	11	view →
OV	DFS	Median	All	0.681	0.923	.044	8	view →
CCRCC	DFS	Quartile	II,III,IV	0.981	0.184	.024	3	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PPA1–PDAC (DFS)

Open the PDAC breakdown →