PPA1

Across TCGA pan-cancer cohorts, PPA1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PPA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPA1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPA1 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where PPA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.821	<.001	12	view →
LUAD	Female	III,IV	+0.573	<.001	9	view →
HNSC	All	III,IV	+0.162	.003	8	view →
CCRCC	Male	All	−0.188	<.001	5	view →
PDAC	All	All	−0.192	.001	4	view →
LSCC	All	All	+0.097	.004	4	view →
OV	All	All	+0.967	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PPA1–COAD

Open the COAD breakdown →