PPA1

Across TCGA patient cohorts, PPA1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPA1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and MEK1. Each is linked with PPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPA1-to-partner and partner-to-PPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPA1-low versus PPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPA1→partner) and Y-score (partner→PPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.459	.048	.020	3	1
UCEC	INPP4B →	-0.343	-3.169	.028	.019	3	1
UCEC	MEK1 →	+0.376	+2.999	.033	.035	3	1
UCEC	STAT3_pY705 →	-0.432	-2.459	<.001	.020	3	1
UCEC	c-Met_pY1235 →	+0.084	+2.179	.018	.034	3	1
UCEC	p62 Lck ligand →	+0.353	+2.459	.024	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by PPA1 expression — UCEC

Explore this box plot interactively →