PPA1

Across TCGA cell cohorts, PPA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,935 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PPA1-associated GO terms across cancer lineages are DNA replication initiation, Positive regulation of mitochondrial RNA catabolic process, and DNA replication, removal of RNA primer. Each is linked with PPA1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PPA1-to-partner and partner-to-PPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PPA1-low versus PPA1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPA1→partner) and Y-score (partner→PPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNA replication initiation →	+0.133	+0.754	.006	.004	2	12
BREAST	Positive regulation of mitochondrial RNA catabolic process →	+0.117	+0.787	<.001	.002	3	11
LIVER	DNA replication, removal of RNA primer →	+0.163	+0.972	.002	.004	3	10
CNS	Maintenance of protein localization in organelle →	-0.062	-0.775	.002	<.001	3	10
LIVER	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.111	+0.898	<.001	<.001	2	10
CNS	Vacuole organization →	-0.043	-0.809	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,935 associations by consensus.

DNA replication initiation by PPA1 expression — URINARY_TRACT

Explore this box plot interactively →