POU6F2

Across TCGA patient cohorts, POU6F2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU6F2-associated genes across cancer lineages are 4E-BP1, MEK1, and PAI-1. Each is linked with POU6F2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU6F2-to-partner and partner-to-POU6F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by POU6F2-low versus POU6F2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU6F2→partner) and Y-score (partner→POU6F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.270	+2.252	.005	.005	3	3
UCEC	MEK1 →	+0.284	+1.925	.031	.005	3	2
UCEC	PAI-1 →	+0.253	+2.000	.040	.009	3	2
LUAD	Bim →	+0.479	+3.169	<.001	.018	3	1
LUAD	4E-BP1_pT37_T46 →	+0.445	+2.824	.023	.034	3	1
LUSC	PKC-delta_pS664 →	-0.174	-3.142	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by POU6F2 expression — UCEC

Explore this box plot interactively →