POU6F2

Across TCGA cell cohorts, POU6F2 mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU6F2-associated genes across cancer lineages are XPO7, PEMT, and DBR1. Each is linked with POU6F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU6F2-to-partner and partner-to-POU6F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XPO7 grouped by POU6F2-low versus POU6F2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU6F2→partner) and Y-score (partner→POU6F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	XPO7 →	+0.656	+2.043	.001	.008	3	2
LARGE_INTESTINE	PEMT →	+0.528	+2.459	.001	.006	3	2
LARGE_INTESTINE	DBR1 →	+0.475	+3.339	<.001	.001	3	2
LARGE_INTESTINE	PRPSAP2 →	+0.507	+2.386	.006	.007	3	2
LARGE_INTESTINE	LYAR →	+0.527	+2.043	.003	.008	3	2
LARGE_INTESTINE	FAIM →	+0.836	+2.459	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

XPO7 by POU6F2 expression — LARGE_INTESTINE

Explore this box plot interactively →