Across TCGA pan-cancer cohorts, POU6F1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POU6F1 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.
The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher POU6F1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POU6F1 expression acts as an unfavorable survival marker.
OV, LUSC, and STAD are the cancer types where POU6F1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.