Across TCGA pan-cancer cohorts, POU6F1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POU6F1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POU6F1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POU6F1 expression acts as an unfavorable survival marker.

CCRCC and LUAD are the cancer types where POU6F1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.232	0.831	.017	4	view →
LUAD	DFS	Median	All	0.208	0.866	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: POU6F1 tumor-vs-normal RNA expression · all POU6F1 data types