Across TCGA patient cohorts, POU6F1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU6F1-associated genes across cancer lineages are eIF4G, GAPDH, and JNK_pT183_Y185. Each is linked with POU6F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU6F1-to-partner and partner-to-POU6F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU6F1→partner) and Y-score (partner→POU6F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.390	+2.700	.005	.006	3	2
UCEC	GAPDH →	+0.566	+2.000	.019	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.274	-2.687	<.001	.006	3	2
UCEC	PCNA →	+0.329	+2.700	<.001	.006	3	2
UCEC	PRDX1 →	+0.212	+2.321	.022	.034	3	2
UCEC	TFRC →	+0.740	+2.000	.001	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

POU6F1 survival (RNA) · tumor vs normal (RNA) · all POU6F1 data types