POU5F2

Across TCGA patient cohorts, POU5F2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU5F2-associated genes across cancer lineages are A-Raf_pS299, PEA-15_pS116, and eEF2. Each is linked with POU5F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU5F2-to-partner and partner-to-POU5F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by POU5F2-low versus POU5F2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F2→partner) and Y-score (partner→POU5F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.144	-3.000	.007	.036	3	2
UCEC	PEA-15_pS116 →	+0.353	+2.000	.025	.032	3	2
UCEC	eEF2 →	+0.379	+2.000	.018	.032	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.462	+2.000	.044	.032	3	1
UCEC	MSH2 →	-0.445	-3.295	<.001	.009	3	1
UCEC	Notch1 →	+0.190	+3.183	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

A-Raf_pS299 by POU5F2 expression — UCEC

Explore this box plot interactively →