POU5F1P4

Across TCGA pan-cancer cohorts, POU5F1P4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated POU5F1P4 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POU5F1P4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POU5F1P4 expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

COAD, BLCA, and KIRC are the cancer types where POU5F1P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.423	0.669	<.001	90	view →
BLCA	OS	Quartile	All	0.832	0.670	<.001	44	view →
KIRC	OS	Tertile	All	0.525	0.659	.014	25	view →
KICH	OS	Tertile	II,III,IV	0.778	0.985	.024	16	view →
UVM	DFS	Tertile	III,IV	0.207	0.751	.023	9	view →
READ	OS	Median	III,IV	0.833	0.309	.011	9	view →
LIHC	DFS	Tertile	All	0.451	0.592	.009	9	view →
CHOL	DFS	Quartile	II,III,IV	0.201	0.595	.004	7	view →
SKCM	OS	Tertile	III,IV	0.896	0.630	.010	7	view →
STAD	OS	Tertile	III,IV	0.693	0.281	.014	6	view →
LUAD	DFS	Median	IV	0.885	0.502	.023	6	view →
ACC	DFS	Quartile	IV	0.038	0.359	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

POU5F1P4–COAD (DFS)

Open the COAD breakdown →