Across TCGA pan-cancer cohorts, POU5F1B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POU5F1B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher POU5F1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POU5F1B expression acts as an unfavorable survival marker.

BLCA, SKCM, and TGCT are the cancer types where POU5F1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.054	0.723	<.001	48	view →
SKCM	DFS	Median	All	0.159	0.768	<.001	9	view →
TGCT	DFS	Median	All	0.146	0.801	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: POU5F1B tumor-vs-normal RNA expression · all POU5F1B data types