Across TCGA patient cohorts, POU5F1B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU5F1B-associated genes across cancer lineages are XBP1, cIAP, and STAT5a. Each is linked with POU5F1B in more than 3 cancer types. Because this analysis shows association rather than direction, both POU5F1B-to-partner and partner-to-POU5F1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1B→partner) and Y-score (partner→POU5F1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.261	-3.156	<.001	.018	3	2
UCEC	cIAP →	+0.160	+3.611	.016	.001	1	4
SKCM	STAT5a →	-0.738	-2.321	.007	.035	3	2
UCEC	A-Raf_pS299 →	-0.205	-3.584	<.001	.002	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.477	+2.179	.020	.034	3	1
UCEC	Rab11 →	-0.147	-2.459	.036	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

POU5F1B survival (RNA) · tumor vs normal (RNA) · all POU5F1B data types