Across TCGA cell cohorts, POU5F1B mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU5F1B-associated genes across cancer lineages are PRSS48, CLLU1-AS1, and SIGLEC8. Each is linked with POU5F1B in more than 1 cancer types. Because this analysis shows association rather than direction, both POU5F1B-to-partner and partner-to-POU5F1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1B→partner) and Y-score (partner→POU5F1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRSS48 →	+0.051	+4.029	<.001	.009	3	1
OVARY	CLLU1-AS1 →	+0.064	+4.228	.001	.006	3	1
SKIN	SIGLEC8 →	+0.022	+4.273	<.001	.006	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
SKIN	C20orf203 →	+0.028	+4.467	.006	.004	3	1
BLOOD_Leukemia	ADIG →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

POU5F1B survival (RNA) · tumor vs normal (RNA) · all POU5F1B data types