Across TCGA cell cohorts, POU5F1B mutation is significantly associated with the mutation status of many other genes, with 2,161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU5F1B-associated genes across cancer lineages are GCC2, NEB, and DGKD. Each is linked with POU5F1B in more than 4 cancer types. Because this analysis shows association rather than direction, both POU5F1B-to-partner and partner-to-POU5F1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1B→partner) and Y-score (partner→POU5F1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GCC2 →	+3.063	+3.498	.006	.006	1	5
CNS	NEB →	+2.740	+4.237	.007	.007	1	4
LARGE_INTESTINE	DGKD →	+2.321	+2.919	.003	.003	1	4
STOMACH	TNS3 →	+4.807	+4.807	.008	.008	1	4
OVARY	POLR3E →	+4.977	+4.415	.007	.007	1	4
LARGE_INTESTINE	RPL22 →	+2.000	+4.087	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,161 associations by consensus.

Exploration

POU5F1B survival (RNA) · tumor vs normal (RNA) · all POU5F1B data types