Across TCGA pan-cancer cohorts, POU5F1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POU5F1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher POU5F1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POU5F1 expression acts as an unfavorable survival marker.

SKCM, ESCA, and UCEC are the cancer types where POU5F1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.197	0.871	<.001	8	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: POU5F1 tumor-vs-normal RNA expression · all POU5F1 data types