Across TCGA patient cohorts, POU5F1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU5F1-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and FoxM1. Each is linked with POU5F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU5F1-to-partner and partner-to-POU5F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1→partner) and Y-score (partner→POU5F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.100	+3.331	.003	.005	3	2
UCEC	EGFR_pY1068 →	-0.337	-2.999	.003	.035	3	1
UCEC	FoxM1 →	+0.285	+2.817	.018	.036	3	1
UCEC	INPP4B →	-0.326	-2.571	.030	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-3.000	.006	.036	3	1
UCEC	JNK2 →	+0.375	+2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

POU5F1 survival (RNA) · tumor vs normal (RNA) · all POU5F1 data types