POU4F1

Across TCGA patient cohorts, POU4F1 mutation is significantly associated with the RNA expression of many other genes, with 3,331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU4F1-associated genes across cancer lineages are CYCSP27, LINC01072, and UBTFL11. Each is linked with POU4F1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU4F1-to-partner and partner-to-POU4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP27 grouped by POU4F1-low versus POU4F1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F1→partner) and Y-score (partner→POU4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CYCSP27 →	+0.307	+3.890	<.001	.002	3	3
UCEC	LINC01072 →	+0.108	+2.225	<.001	<.001	3	3
CESC	UBTFL11 →	+0.043	+4.037	<.001	.005	3	2
UCEC	IGHD5-5 →	+0.126	+4.066	<.001	.003	3	2
UCEC	RNA5SP369 →	+0.275	+1.719	<.001	.003	3	2
UCEC	SNORA84 →	+0.474	+1.470	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,331 associations by consensus.

CYCSP27 by POU4F1 expression — LUSC

Explore this box plot interactively →