POU4F1

Across TCGA patient cohorts, POU4F1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU4F1-associated genes across cancer lineages are TIGAR, eEF2, and EGFR_pY1068. Each is linked with POU4F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU4F1-to-partner and partner-to-POU4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by POU4F1-low versus POU4F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F1→partner) and Y-score (partner→POU4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.169	+1.833	.001	.002	3	2
UCEC	eEF2 →	+0.329	+2.584	.006	.010	3	1
UCEC	EGFR_pY1068 →	-0.232	-2.584	.006	.010	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.502	<.001	.001	3	1
UCEC	ERK2 →	+0.181	+2.000	.005	.009	3	1
UCEC	Gab2 →	+0.307	+2.321	.011	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TIGAR by POU4F1 expression — UCEC

Explore this box plot interactively →