POU4F1

Across TCGA cell cohorts, POU4F1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,311 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POU4F1-associated GO terms across cancer lineages are Branching morphogenesis of an epithelial tube, Establishment of spindle localization, and Regulation of chromosome condensation. Each is linked with POU4F1 in more than 6 cancer types. Because this analysis shows association rather than direction, both POU4F1-to-partner and partner-to-POU4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branching morphogenesis of an epithelial tube grouped by POU4F1-low versus POU4F1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F1→partner) and Y-score (partner→POU4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Branching morphogenesis of an epithelial tube →	-0.084	-1.963	<.001	<.001	3	7
SOFT_TISSUE	Establishment of spindle localization →	+0.096	+2.583	<.001	.001	3	7
SOFT_TISSUE	Regulation of chromosome condensation →	+0.181	+2.937	<.001	<.001	3	7
BONE	Connective tissue development →	-0.093	-2.194	<.001	<.001	3	7
BONE	DNA-templated transcription initiation →	+0.067	+2.055	<.001	<.001	3	7
OVARY	Neuron fate specification →	-0.244	-1.155	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,311 associations by consensus.

Branching morphogenesis of an epithelial tube by POU4F1 expression — BONE

Explore this box plot interactively →