POU4F1

Across TCGA cell cohorts, POU4F1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POU4F1-associated genes across cancer lineages are OBP2B, ANGPTL5, and KRTAP12-3. Each is linked with POU4F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU4F1-to-partner and partner-to-POU4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2B grouped by POU4F1-low versus POU4F1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F1→partner) and Y-score (partner→POU4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OBP2B →	+0.046	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1
OVARY	XAGE5 →	+0.153	+5.196	<.001	.005	3	1
OVARY	NLRP8 →	+0.006	+5.196	<.001	.005	3	1
OVARY	SUPT20HL1 →	+0.123	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OBP2B by POU4F1 expression — BLOOD_Leukemia

Explore this box plot interactively →