POU4F1

Across TCGA cell cohorts, POU4F1 mutation is significantly associated with the mutation status of many other genes, with 2,429 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU4F1-associated genes across cancer lineages are SKOR1, EBF3, and KDM6A. Each is linked with POU4F1 in more than 4 cancer types. Because this analysis shows association rather than direction, both POU4F1-to-partner and partner-to-POU4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKOR1 grouped by POU4F1-low versus POU4F1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F1→partner) and Y-score (partner→POU4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SKOR1 →	+4.044	+5.000	.008	.008	1	5
STOMACH	EBF3 →	+4.807	+4.807	.008	.008	1	5
CNS	KDM6A →	+5.044	+5.614	.003	.003	1	5
UPPER_AERODIGESTIVE_TRACT	DOCK11 →	+4.392	+4.954	.008	.008	1	5
CNS	OR5I1 →	+4.459	+5.277	.005	.005	1	4
CNS	SOST →	+6.044	+6.044	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,429 associations by consensus.

SKOR1 by POU4F1 expression — CNS

Explore this box plot interactively →