Across TCGA patient cohorts, POU3F2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU3F2-associated genes across cancer lineages are FASN, ATM, and TFRC. Each is linked with POU3F2 in more than 3 cancer types. Because this analysis shows association rather than direction, both POU3F2-to-partner and partner-to-POU3F2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F2→partner) and Y-score (partner→POU3F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.557	+2.815	.009	.036	3	4
UCEC	ATM →	-0.513	-2.687	.001	.005	3	3
UCEC	TFRC →	+0.562	+3.321	.003	.009	3	2
UCEC	C-Raf →	+0.256	+4.087	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.164	-3.446	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.317	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

POU3F2 survival (RNA) · tumor vs normal (RNA) · all POU3F2 data types