Across TCGA pan-cancer cohorts, POU3F1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POU3F1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher POU3F1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POU3F1 expression acts as an unfavorable survival marker.

ESCA and BLCA are the cancer types where POU3F1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.163	0.525	.012	12	view →
BLCA	OS	Median	IV	0.120	0.599	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: POU3F1 tumor-vs-normal RNA expression · all POU3F1 data types