Across TCGA patient cohorts, POU3F1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU3F1-associated genes across cancer lineages are A-Raf_pS299, p27_pT157, and CD31. Each is linked with POU3F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU3F1-to-partner and partner-to-POU3F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F1→partner) and Y-score (partner→POU3F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-2.321	.007	.034	3	2
UCEC	p27_pT157 →	-0.054	-1.960	.024	.030	3	2
UCEC	CD31 →	-0.156	-2.449	.010	.019	3	2
UCEC	C-Raf →	+0.253	+2.321	<.001	.006	3	2
UCEC	ER-alpha_pS118 →	+0.302	+2.335	.041	.018	3	1
UCEC	ACC_pS79 →	+0.452	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

POU3F1 survival (RNA) · tumor vs normal (RNA) · all POU3F1 data types