Across TCGA cell cohorts, POU3F1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible POU3F1-associated genes across cancer lineages are DEFA3, ZPBP2, and PRAMEF15. Each is linked with POU3F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU3F1-to-partner and partner-to-POU3F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F1→partner) and Y-score (partner→POU3F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
CNS	ZPBP2 →	+0.089	+5.754	<.001	.002	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.223	+5.321	<.001	.005	3	1
CNS	CELA3B →	+0.182	+5.754	<.001	.002	3	1
CNS	PRAMEF5 →	+0.459	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

POU3F1 survival (RNA) · tumor vs normal (RNA) · all POU3F1 data types