POU2F3

Across TCGA patient cohorts, POU2F3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU2F3-associated genes across cancer lineages are Cyclin-B1, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with POU2F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F3-to-partner and partner-to-POU2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by POU2F3-low versus POU2F3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F3→partner) and Y-score (partner→POU2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.722	+2.182	<.001	.033	3	2
UCEC	STAT3_pY705 →	-0.361	-2.405	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.485	+1.926	.018	.008	3	2
UCEC	4E-BP1 →	+0.381	+2.459	<.001	<.001	3	2
SKCM	eIF4G →	+0.600	+3.000	.003	.034	3	1
SKCM	PI3K-p85 →	+0.234	+2.820	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by POU2F3 expression — SKCM

Explore this box plot interactively →