POU2F3

Across TCGA cell cohorts, POU2F3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible POU2F3-associated genes across cancer lineages are COX4I2, OR10K2, and PABPC1L2A. Each is linked with POU2F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F3-to-partner and partner-to-POU2F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by POU2F3-low versus POU2F3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F3→partner) and Y-score (partner→POU2F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
BREAST	SPATA31A5 →	+0.013	+5.169	<.001	.005	3	1
LARGE_INTESTINE	PIK3C2G →	+0.057	+3.766	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

COX4I2 by POU2F3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →