POU2F2

Across TCGA patient cohorts, POU2F2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU2F2-associated genes across cancer lineages are ATM, JNK2, and PCNA. Each is linked with POU2F2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU2F2-to-partner and partner-to-POU2F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by POU2F2-low versus POU2F2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F2→partner) and Y-score (partner→POU2F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.562	-3.687	<.001	.001	3	3
UCEC	JNK2 →	+0.176	+1.874	.008	.002	3	2
UCEC	PCNA →	+0.259	+2.201	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.327	-1.321	<.001	.029	3	2
UCEC	ASNS →	+0.349	+1.765	.003	.013	3	2
UCEC	EGFR_pY1068 →	-0.229	-1.807	.006	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ATM by POU2F2 expression — UCEC

Explore this box plot interactively →