POU2AF1

Across TCGA patient cohorts, POU2AF1 mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU2AF1-associated genes across cancer lineages are RN7SL229P, IGHD3-9, and LINC01134. Each is linked with POU2AF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2AF1-to-partner and partner-to-POU2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL229P grouped by POU2AF1-low versus POU2AF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2AF1→partner) and Y-score (partner→POU2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL229P →	+0.069	+3.990	<.001	.009	3	2
UCEC	IGHD3-9 →	+1.681	+2.857	<.001	<.001	3	2
UCEC	LINC01134 →	+0.353	+3.212	.003	.009	3	2
UCEC	RN7SL794P →	+0.432	+2.459	<.001	.001	3	2
UCEC	RN7SL447P →	+0.240	+2.570	<.001	.004	3	2
SKCM	RNA5SP285 →	+0.143	+5.003	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

RN7SL229P by POU2AF1 expression — SKCM

Explore this box plot interactively →