POU2AF1

Across TCGA cell cohorts, POU2AF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,351 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POU2AF1-associated GO terms across cancer lineages are Mitotic DNA damage checkpoint signaling, Positive regulation of endoplasmic reticulum unfolded protein response, and Positive regulation of mRNA metabolic process. Each is linked with POU2AF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both POU2AF1-to-partner and partner-to-POU2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA damage checkpoint signaling grouped by POU2AF1-low versus POU2AF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2AF1→partner) and Y-score (partner→POU2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitotic DNA damage checkpoint signaling →	+0.087	+0.949	.002	.008	3	8
LIVER	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.131	+1.395	.002	.003	3	7
LUNG_NSCLC_LUSC	Positive regulation of mRNA metabolic process →	+0.060	+0.572	<.001	.005	3	7
LUNG_NSCLC_LUSC	RNA destabilization →	+0.062	+0.576	<.001	.005	3	7
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.169	+2.156	<.001	<.001	2	7
PANCREAS	Positive regulation of transcription elongation by RNA polymerase II →	+0.070	+0.216	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,351 associations by consensus.

Mitotic DNA damage checkpoint signaling by POU2AF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →