POU2AF1

Across TCGA cell cohorts, POU2AF1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU2AF1-associated genes across cancer lineages are ITGAD, SFTPC, and RNASE9. Each is linked with POU2AF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2AF1-to-partner and partner-to-POU2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by POU2AF1-low versus POU2AF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2AF1→partner) and Y-score (partner→POU2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	SFTPC →	+0.227	+4.169	<.001	.002	3	1
LUNG_SCLC	RNASE9 →	+0.029	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ITGAD by POU2AF1 expression — LARGE_INTESTINE

Explore this box plot interactively →