POU1F1

Across TCGA pan-cancer cohorts, POU1F1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POU1F1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POU1F1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POU1F1 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where POU1F1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POU1F1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.978	<.001	11	view →
PDAC	Male	All	−1.317	<.001	9	view →
LSCC	Male	All	−1.247	<.001	8	view →
COAD	All	IV	+1.890	.001	7	view →
LUAD	Female	All	−0.595	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POU1F1–HNSC

Open the HNSC breakdown →