Across TCGA patient cohorts, POTEM mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEM-associated genes across cancer lineages are OR2A41P, RN7SL813P, and CTRB1. Each is linked with POTEM in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEM-to-partner and partner-to-POTEM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEM→partner) and Y-score (partner→POTEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR2A41P →	+0.316	+4.582	<.001	.005	3	2
SKCM	RN7SL813P →	+0.101	+4.385	<.001	.008	3	1
UCEC	CTRB1 →	+0.598	+3.836	<.001	.005	3	1
COAD	MIR4725 →	+0.559	+6.251	<.001	.001	3	1
LUAD	PRR23D3P →	+0.184	+7.930	<.001	.008	3	1
UCEC	IL17A →	+0.282	+4.031	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

POTEM survival (RNA) · tumor vs normal (RNA) · all POTEM data types