Across TCGA pan-cancer cohorts, POTEI mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of POTEI’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POTEI mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POTEI is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where POTEI tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POTEI mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.822	<.001	9	view →
LUAD	Male	III,IV	−0.513	<.001	9	view →
HNSC	Male	IV	−1.041	<.001	8	view →
LSCC	Male	III,IV	−0.797	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: POTEI RNA expression & survival · all POTEI data types