Across TCGA cell cohorts, POTEG mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible POTEG-associated genes across cancer lineages are PRAMEF1, GP2, and CST2. Each is linked with POTEG in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEG-to-partner and partner-to-POTEG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEG→partner) and Y-score (partner→POTEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF1 →	+0.020	+2.938	.001	.003	3	1
LUNG_SCLC	GP2 →	+1.102	+3.369	.002	.005	3	1
LUNG_SCLC	CST2 →	+0.033	+3.232	<.001	.001	3	1
LUNG_SCLC	OR51F2 →	+0.260	+2.887	<.001	.004	3	1
LUNG_SCLC	GOLGA8G →	+0.020	+2.807	.001	.004	3	1
LUNG_SCLC	KRTAP10-8 →	+0.053	+3.421	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

POTEG survival (RNA) · tumor vs normal (RNA) · all POTEG data types