Across TCGA patient cohorts, POTEF mutation is significantly associated with the RNA expression of many other genes, with 4,879 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEF-associated genes across cancer lineages are SRIP2, PPP2R5D, and DPF1. Each is linked with POTEF in more than 3 cancer types. Because this analysis shows association rather than direction, both POTEF-to-partner and partner-to-POTEF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEF→partner) and Y-score (partner→POTEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SRIP2 →	+0.042	+1.943	.002	.004	3	4
UCEC	PPP2R5D →	+0.494	+2.039	<.001	<.001	3	4
UCEC	DPF1 →	+0.331	+1.659	.002	.001	3	4
UCEC	TMEM11 →	+0.383	+1.702	<.001	<.001	3	4
UCEC	RNVU1-28 →	+0.353	+1.383	.002	<.001	3	3
LUAD	GTF3C2 →	+0.385	+2.854	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,879 associations by consensus.

Exploration

POTEF survival (RNA) · tumor vs normal (RNA) · all POTEF data types