Across TCGA patient cohorts, POTEF mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEF-associated genes across cancer lineages are Cyclin-E2, Bap1-c-4, and PCNA. Each is linked with POTEF in more than 3 cancer types. Because this analysis shows association rather than direction, both POTEF-to-partner and partner-to-POTEF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEF→partner) and Y-score (partner→POTEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E2 →	+0.191	+3.476	.002	.002	3	4
LUAD	Bap1-c-4 →	+0.222	+2.338	.014	.019	3	3
UCEC	PCNA →	+0.191	+1.678	.002	.019	3	3
UCEC	TFRC →	+0.441	+2.321	.005	.005	3	3
UCEC	ATM →	-0.432	-1.807	.001	<.001	3	3
UCEC	4E-BP1 →	+0.325	+4.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

POTEF survival (RNA) · tumor vs normal (RNA) · all POTEF data types