Across TCGA cell cohorts, POTEF mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible POTEF-associated genes across cancer lineages are DMRTC2, OR2AJ1, and WFDC10A. Each is linked with POTEF in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEF-to-partner and partner-to-POTEF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEF→partner) and Y-score (partner→POTEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DMRTC2 →	+0.006	+5.643	.003	.002	3	2
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
LUNG_SCLC	WFDC10A →	+1.146	+3.817	<.001	.004	3	1
LUNG_SCLC	CRYGB →	+0.050	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP19-2 →	+0.102	+4.058	<.001	.007	3	1
LUNG_SCLC	BOD1L2 →	+0.006	+4.070	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

POTEF survival (RNA) · tumor vs normal (RNA) · all POTEF data types